Rh(III)-Catalyzed Coupling of Benzamides with Propargyl Alcohols via Hydroarylation–Lactonization

Abstract

Rh(III)-catalyzed C-H activation and annulation of 1-benzoylpyrrolidine with propargyl alcohols has been achieved for an efficient synthesis of (4-benzylidene)isochroman-1-one. Highly enantioenriched products were obtained starting from optically pure propargyl alcohols.