A comparison between target-controlled and manually controlled propofol infusions in patients undergoing routine surgical procedures

Abstract

Anaesthesia significantly increased latency of Pa and Nb compared with when patients were awake (P < 0.01). After extubation, the latency of Pa and Nb significantly decreased and basically returned to baseline level. BIS and latency of both Pa and Nb did not differ between groups.Also, the propofol induction dose (mean WSD: TCI, 2.09 +/- 0.36 mg kg(-1); MCI, 2.06 +/- 0.16 mg kg(-1) and total dose (TCI, 5.57 +/- 0.96 mg kg(-1) h(-1); MCI, 5.79 +/- 0.87 mg kg(-1) h(-1) and measured plasma propofol concentration during anaesthesia did not differ between groups. At 15 min after intubation, the mean predicted plasma concentration (2.2 +/- 0.2 microg ml(-1)) differed significantly from the measured plasma concentration (2.8 +/- 1.2 microg ml(-1)). No correlation was observed between predicted and measured propofol plasma concentrations.