Effect of Anti-Skin Wrinkle and Antioxidant of Agastache rugosa Kentz through Fermentation Process of the lactic acid

Abstract

This study was to investigate anti-skin wrinkle effect of Agastache rugosa Kentz extracts by extraction processes. In the comparison of the effect of the solvent extraction, the extracts by 70% ethanol (EE) showed better biological activitiesthat those by hot water. Therefore, further fermented Agastache rugosa was applied to 70% ethanol extraction process(FEE). FEE showed higher DPPH scavenging activity of 62.98% than EE’s 62.71% at 1.0 ㎎/㎖, but there was no significant. Elastase inhibition was measured 23.0% from FEE at 1.0 ㎎/㎖. Cytotoxicity showed the highest 16.26% from FEE, thisvalue is safe in the cell experiment. Collagen production showed 113.1 ng/㎖ from FEE, on the other hand EE was measured77.4 ng/㎖ in adding 1.0 ㎎/㎖. MMP-1 production was observed 1398 pg/㎖ from FEE and EE was measured1632 pg/㎖. These results were found the highest antioxidant and anti-wrinkle effect. As a result, it was also confirmed thatanti-skin wrinkle activities of the Agastache rugosa Kentz extract was correlated with anti-oxidant activities.