Nickel-Catalyzed Direct Thiolation of C(sp³)–H Bonds in Aliphatic Amides

Abstract

Nickel-catalyzed thiolation of the inactivated methyl C(sp(3))-H bonds of aliphatic amides with disulfide is described. It is a novel strategy for the synthesis of thioethers with the ultimate goal of generating thioether carboxylic acids with various functional groups.