Oxidative Remote C−H Trifluoromethylation of Quinolineamides on the C5 Position with Iodobenzene Diacetate as the Oxidizing Agent

Abstract

Abstract A facile, metal‐free protocol has been developed for the remote trifluoromethylation of 8‐aminoquinoline scaffolds on the C5 position, which is difficult to functionalize. In this method, 8‐aminoquinolineamides reacted with an inexpensive and commercially available CF 3 source (Langlois reagent) to give a wide range of trifluoromethylated aminoquinolineamides.