DATATOC: a novel conjugate for kit-type 68Ga labelling of TOC at ambient temperature

Abstract

BACKGROUND: Ga-PET depends on our ability to develop radiopharmaceuticals that can be prepared in a convenient and suitable manner. A kit-type labelling protocol provides such characteristics and requires chelators that can be radiolabelled under exceptionally mild conditions. Recently the DATA chelators have been introduced that fulfil these requirements. In continuing their development, the synthesis and radiolabelling of the first DATA bifunctional chelator (BFC) and peptide conjugate are described. RESULTS: = 10.3 min). Kit-type labelling from a lyophilised solid using acetone-PP based labelling achieves > 95 % RCY in 10 min at 23 °C. CONCLUSIONS: Ga-DATATOC can be prepared makes it a very attractive alternative to current standards.