Studies on the Metabolism of Meprobamate

Abstract

Urinary excretion ratios of meprobamate and its major metabolic product, hydroxymeprobamate, were determined in a number of laboratory animal species following administration of meprobamate by several routes. No major differences were apparent. Humans receiving relatively small doses of this drug excreted a higher proportion of unchanged meprobamate, especially after a single administration of the drug. Chronic administration of meprobamate to humans appeared to stimulate its metabolism.