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Luteolytic Effects of Prostaglandin F2 in Primates
111
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1970
Year
SpermatogenesisCorpus LuteumFertilitySummaryprostaglandin F2αReproductive HealthGynecologyFemale Reproductive FunctionReproductive BiologyGastrointestinal Peptide HormoneReproductive EndocrinologyReproductive PhysiologyFemale InfertilityRhesus MonkeysHypothalamic PeptideReproductive MedicinePublic HealthProstaglandin F2EndocrinologyPharmacologyPhysiologyUterine ReceptivityMedicineEndocrine ResearchReproductive Hormone
SummaryProstaglandin F2α was luteolytic in rhesus monkeys when injected 30 mg/day subcutaneously b.i.d. for 5 days, if the injections were initiated on day 11, 12, or 13 postovulation of fertile cycles. At this time circulating progestin levels are elevated, presumably due to a trophic stimulus from the blastocyst. Such an effect was not obtained by injection earlier in the luteal phase of the reproductive cycle. This indicates that the corpus luteum of this species is more vulnerable to luteolysis in the later stages of the reproductive cycle.