Effects of Hyperbaric Oxygenation on Metabolism I. ATP Concentration in Rat Brain, Liver and Kidney.

Abstract

1) Tissue ATP concentrations were determined in the cerebral hemispheres, liver and kidney in rats exposed to air at 1 atmosphere, and to 100% oxygen for 2 hours at 1 and 3 atmospheres, and 1 1/2 hours at 5 atmospheres. 2 Liver and kidney had normal ATP levels at 1 atmosphere and increased ATP levels at 3 atmospheres (39% and 18% respectively). 3 Cerebral hemispheres had markedly depressed ATP concentrations at 1 atmosphere (57%) and 3 atmospheres (34%). 4 Significant decreases in ATP levels occurred in cerebral hemisphere (54%), liver (44%), and kidney (63%) of rats exposed to 100% oxygen for 1 1/2 hours at 5 atmospheres. 5 The significance of the findings is discussed.