Reactions of Human Sera to Avian Adenoviruses and Newcastle Disease Virus

Abstract

The sera of two human populations were examined for antiviral reactions to avian adenoviruses and to Newcastle disease virus (NDV). Group I had close contact with poultry; Group II had limited association. None of the sera reacted with the avian adenoviruses used. Sera of Group I individuals had a high frequency of NDV hemagglutinin inhibitory (HI) activity; Group II sera showed no such reactions. Sera of both groups showed a low frequency of reactors having NDV neutralizing antibody. Neutralizing activity could not be related to HI activity of the sera. The HI activity observed was apparently not due to cross reactions with mumps antibody.