Molecular and Clinical Oncology · 2016 · 28 citations · 20 references
MedicineOncologyRadiation OncologyClinical Radiation OncologyPalliative MedicinePalliative OncologyMetastatic Cancer ManagementMetastatic Disease ManagementPalliative RadiotherapyPancreatic CancerRadiation TherapyToxicity ManagementMetastatic Disease PalliationMetastatic Pancreatic CancerPain Control EfficacyPalliative Radiotherapy For PainPalliative Radiotherapy ToxicityPalliative TherapyPancreatic Cancer RadiotherapySerious Adverse Events
This study was conducted to investigate hypofractionated radiotherapy (RT) in patients with locally advanced or metastatic adenocarcinoma of the pancreas. A total of 31 patients were enrolled in this study, 26 of whom had locally advanced (M0) pancreatic cancer and 5 had metastatic (M1) disease. The patients were treated with palliative RT (6-30 Gy in 1-10 fractions over a period of 1 day-2 weeks). Treatment-related toxicity was classified according to the Common Terminology Criteria for Adverse Events, version 3.0. Early mild toxicity was observed. A total of 17 patients (55%) achieved good pain control without pharmacological therapy, and 12 patients (39%) reduced their use of analgesics; in the remaining 2 patients (6%), there was no change in analgesic use. Late high-grade (>3) toxicity was not observed. The average survival time for the 31 patients was 9 months. The 1-year overall survival rate was 16%. Palliative RT was well-tolerated and was able to prolong the survival time. The majority of the patients achieved better pain control with palliative RT.
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Stephen Sener, Amy M. Fremgen, Herman R. Menck et al. · Journal of the American College of Surgeons · 1999 · 793 citations