Changes in Spinal Cord Expression of Fractalkine and its Receptor in a Rat Model of Disc Herniation by Autologous Nucleus Pulposus

Abstract

Our results indicate that autologous implantation of NP induces thermal hyperalgesia and mechanical allodynia, and leads to an upregulation of fractalkine and its receptor in spinal neurons and glia, implicating fractalkine in association with radicular pain.