Chemical and Pharmaceutical Bulletin · 1982 · 55 citations · 0 references
Bioorganic ChemistryAntibacterial ActivityAntimicrobial ChemotherapyPharmaceutical ChemistryMedicinal ChemistryBiosynthesisAntimicrobial Resistance-Propylphosphonic AcidPhosphonic Acid AntibioticsStructure-activity RelationshipAntibacterial AgentAntimicrobial CompoundPharmacologyNatural Product SynthesisPropylphosphonic AcidAntibioticsNatural SciencesMicrobiologyMedicineSynthetic Chemistry
The synthesis of analogs of 3-(N-acetyl-N-hydroxyamino) propylphosphonic acid (FR-900098, Ia) and an analysis of their structure-activity relationship are described. Among them, compounds Ib (FR-31564) and XIIb (FR-32863) have recently been found to be produced naturally by Streptomyces lavendulae. The antibacterial activity of Ib against Pseudomonas species is especially significant.