Asymmetric Total Synthesis of (-)-Galanthamine via Intramolecular Heck Reaction of Conjugated Diene

Abstract

Asymmetric total synthesis of (–)-galanthamine was accomplished starting from an epoxide. Intramolecular Heck reaction of a conjugated diene system was employed to construct the key quaternary carbon center. The cyclohexene-1,3-diol unit of (–)-galanthamine is derived from an optically active epoxy alkenol.