Synergistic Effect of Cortisol and Growth Hormone on Hepatic Ornithine Decarboxylase Activity

Abstract

SummaryLiver ornithine decarboxylase activity is stimulated by hydrocortisone as well as by growth hormone. Hypophysectomy lowers basal levels but adrenalectomy does not. Simultaneous administration of both growth hormone and hydrocortisone increases the activity more than the sum of the increase due to each hormone alone. Pharmacological dosages of testosterone, epinephrine, insulin, l-thyroxine, estradiol, and glucagon produced only minor alterations in hepatic ODC levels.