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Unfused heterobicycles as amplifiers of phleomycin. I. Some pyridinyl- and pyrazolyl-pyrimidines, bithiazoles and thiazolylpyridines
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1980
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Bioorganic ChemistryEngineeringAntibiotic AdjuvantEscherichia ColiOrganic ChemistryHeterocycle ChemistryPharmaceutical ChemistryDrug ResistanceMedicinal ChemistryBiosynthesisAntimicrobial ResistanceBiochemistryAntibacterial AgentAntimicrobial CompoundPharmacologyBiomolecular EngineeringHeterocyclicSimple DerivativesNatural SciencesSynthetic BiologyMicrobiologyUnfused HeterobicyclesPyrazol-4'- Yl
Syntheses are reported for some simple derivatives of 2-(pyridin-2'- yl)pyrimidine; 4-(pyrazol-1'- yl)pyrimidine; 4-(pyrazol-4'- yl)pyrimidine; 4,5'-bithiazole; 2-, 3-, and 4-(thiazol-4'-yl)pyridine and 2-, 3-, and 4-(thiazol-2'-yl)pyridine. Biological activities, as amplifiers of phleomycin against in vitro cultures of Escherichia coli, are tabulated and discussed.