Fibroregulation of Mesenchymal Progenitor Cells by BMP-4 After Traumatic Muscle Injury

Abstract

BMP-4 has an effect on MPCs that seems to promote fibrotic tissue formation. These findings suggest that BMP-4, while promoting osteoinduction, may also act on MPCs to promote formation of a fibrotic osteoinductive matrix. Thus, this signaling axis might be a potential target for heterotopic ossification prevention.