Determination and Physiologic Disposition of Meprobamate.

Abstract

(1) A specific method for the determination of meprobamate in urine is described. (2) Metabolic studies indicate that about 12 to 20 percent of the unchanged drug is slowly excreted in the urine in 48 hours and that additional products are formed, including several conjugates at least one of which is a glucuronide. (3) Radioactive meprobamate has been prepared and metabolic studies have been performed. The liver is the principal site of metabolic alteration.