Etodolac:β-cyclodextrin inclusion complex as a novel fluorescent chemosensor probe for Ba²⁺

Abstract

The inclusion complex of etodolac (ETD) with β-CD was investigated by UV-visible and fluorescence spectroscopy. The chemosensory ability of ETD:β-CD complex for various metal cations was investigated thoroughly, and we found that the emission of the complex showed a drastic increase in the intensity for Ba2+. Competitive experiments of ETD:β-CD complex with Ba2+ showed that no significant variation was found in the fluorescence intensity of the ETD:β-CD/Ba2+ complex upon adding other cations, such as Na+, Ag+, Hg2+, Cd2+, Al3+, Cr3+, Fe3+, Se4+, and Ti4+. The linearity range, limit of detection (LOD), and limit of quantitation (LOQ) were determined from the selectivity and sensitivity studies.