Experimental Biology and Medicine · 1958 · 28 citations · 0 references
Life SciencesPharmacologyPhysiologyMetabolic PhysiologyMetabolismPharmacodynamicsCarbon Dioxide RetentionCarbon Dioxide TransportGas ExchangeGas Exchange PhysiologyHemodynamicsRespiratory PhysiologyArterial Carbon Dioxide ContentCarbonic Anhydrase FunctionCarbonic Anhydrase InhibitorsGas Transport In BloodRespiratory Gas ExchangeTissue Gas ExchangeTissue Tension AssessmentVenous Carbon Dioxide Content
1. Venous and tissue gas tensions in the rat have been estimated by use of artificially constructed subcutaneous gas pocket. Inhibition of carbonic anhydrase by acetazolamide results in a rise in venous and tissue CO2 tension independent of change of oxygen tension. This effect is associated with hyperventilation and an increase in arterial CO2 content. 2. These findings are interpreted as direct evidence of CO2 retention resulting from interference in CO2 transport by carbonic anhydrase inhibition.