Daily Changes in 5-Hydroxytryptamine Concentration in Mouse Brain.

Abstract

ZBC mice, male or female, 5 or 7 weeks of age, were studied under conditions standardized for evaluation of 24-hour periodicity. A small but significant decrease in 5-HTA concentration of brain pools was noted prior to usual time of arousal. A sex difference in brain 5-HTA concentration also was recorded, the females exhibiting slightly higher values.