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Bradykinin as a Mediator of Human Pain.
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1967
Year
Pain DisordersPain MedicineNeuropathic PainMolecular PainHuman PainPharmacotherapyMolecular PharmacologyPain SyndromeIntraperitoneal InjectionPain ManagementHealth SciencesNeuropharmacologyPharmacologyUniversal MediatorPain ResearchSubstances ProducesPhysiologyPain MechanismMedicine
In man, the polypeptides brady-kinin and kallidin, but not eledoisin, produce pain on intraperitoneal injection. None of these substances produces pain when injected subcutaneously or intramuscularly in higher concentrations. Therefore, none of these polypeptides can be considered as a universal mediator of pain.