Publication | Closed Access
A One-Pot Parallel Reductive Amination of Aldehydes with Heteroaromatic Amines
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Citations
19
References
2014
Year
Combinatorial ChemistryCross-coupling ReactionEngineeringMedicineOrganic ChemistryHeteroaromatic AminesCatalysisDiverse Secondary AminesChemistryParallel Reductive AminationStereoselective SynthesisPharmacologySynthetic ChemistryBiomolecular EngineeringDrug Discovery
A parallel reductive amination of heteroaromatic amines has been performed using a combination of ZnCl2-TMSOAc (activating agents) and NaBH(OAc)3 (reducing agent). A library of diverse secondary amines was easily prepared on a 50-300 mg scale.
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