Experimental Biology and Medicine · 1950 · 41 citations · 0 references
MedicineEndocrinologyPhysiologyMineral MetabolismRenal PathologyRenal PathophysiologyAdrenal DisordersAdrenal EndocrinologyAdrenal HormonesAdrenal Steroid HormonesNephrotic SyndromeRenal DiseaseAdrenal Cortex FunctionAdrenal Cortex PhysiologyAdrenal Hormone MetabolismAdrenal PathophysiologyAdrenal Steroid MetabolismNephrotic Syndrome Protein LossNephrotic Syndrome TreatmentNitrogen Mass Balance
It is concluded that an appropriate stimulus to the adrenal cortex by the administration of adrenocorticotropin is capable of producing marked modifications in the nephrotic syndrome. These modifications include reduction in serum cholesterol and urine protein, increase in serum proteins and profound diuresis. With one exception the diuresis occurred after discontinuance of ACTH, and the improvement in nitrogen balance and serum values continued for several weeks.