Intraductal Administration of an NK1 Receptor Antagonist Attenuates the Inflammatory Response to Retrograde Infusion of Radiological Contrast in Rats: Implications for the Pathogenesis and Prevention of ERCP-Induced Pancreatitis

Abstract

When an NK1 receptor antagonist is delivered along with the contrast media there is significant reduction in the pancreatic inflammation caused by intraductal contrast infusion. These results provide some insight into the pathogenesis of ERCP induced pancreatitis as well as present novel pharmacological targets for its prevention.