Ability of Isopregnenolone-21-Carboxylates to Block Renal Effects of Deoxycorticosterone and Aldosterone in Rats

Abstract

Studies demonstrate that isopregnenolone-21-carboxylates are potent inhibitors of the renal electrolyte effects of deoxycorticosterone in adrenalectomized rats. Compound III, the most active in the series, was also effective against aldosterone. Available evidence indicates that the compounds affect electrolyte excretion by competition with aldosterone-like steroids at receptor sites in target tissue.