Tc99m-Sestamibi Thigh SPECT/CT Images for Noninvasive Assessment of Skeletal Muscle Injury in Carbon Monoxide Intoxication With Clinical and Pathological Correlation

Abstract

In this study, we demonstrated that patients with CO intoxication sustained defective mitochondrial metabolism in skeletal muscles as revealed by a decrement in Tc-99m sestamibi uptake either by visual or semiquantification of thigh SPECT/CT. Tc-99m sestamibi scanning provided noninvasive measurement of mitochondrial injury in muscles after CO intoxication and the correlation with clinical parameters was good.