Pretreatment With TLR2 and TLR4 Ligand Modulates Innate Immunity in Corneal Fibroblasts Challenged With<i>Aspergillus fumigatus</i>

Abstract

Pretreatment of THSFs with TLR2-specific ligand zymosan results in a state of A. fumigatus hyphae tolerance. Copretreatment with TLR2 and -4 ligands (zymosan and LPS) leads to a stronger state of A. fumigatus hyphae tolerance, and suppresses the lethal effect of A. fumigatus.