Comparison of Different Types of Central Stimulation from Analeptics.

Abstract

1. A method is described for measuring stimulation produced by analeptics, which consists of suspending white rats or other small animals in small cages from wire springs and summating the amount of movement by connecting the springs to Harvard work adders. The activities resulting over periods of hours, are recorded by electrical contacts on the work adders through signal magnets writing on a kymograph drum. The apparatus is kept in a lighted constant temperature chamber between 27 and 29° C as conditions for minimum activity. The amounts of activity shown by the animals after injections of normal saline solution are designated as control levels of activity, and subtracted from those observed during the action of a drug to give the net stimulation produced by the agent in question.