C-13.BETA.-Acyloxymilbemycine, a new family of macrolides. Discovery, structural determination and hological properties.

Abstract

A family of novel milbemycins possessing C-13 beta-acyloxy substitution was produced by Streptomyces hygroscopicus ATCC 53718. These compounds were detected by HPLC diode array analysis and possess anthelmintic and ectoparasiticidal activity. The origin of the oxygen atom at C-13 is discussed.