Combination Therapy with Cyclosporine and Methotrexate in Severe Rheumatoid Arthritis

Abstract

In a six-month study, patients with severe rheumatoid arthritis and only partial responses to methotrexate had clinically important improvement after combination therapy with cyclosporine and methotrexate. Side effects were not substantially increased. Long-term follow-up of patients treated with this combination is needed.