Intermolecular Aminotrifluoromethylation of Alkenes by Visible-Light-Driven Photoredox Catalysis

Abstract

Intermolecular aminotrifluoromethylation of alkenes catalyzed by [Ru(bpy)3](2+) under visible light irradiation has been explored. The present photocatalytic protocol achieves highly efficient and regioselective difunctionalization of C═C bonds, leading to a variety of β-trifluoromethylamines. The reaction is applied to "late-stage aminotrifluoromethylation" of steroid and amino acid scaffolds.