Palladium-Catalyzed Tandem Annulation: A Strategy To Construct 2,3-Difunctionalized Benzofuran Derivatives in Ionic Liquids

Abstract

An efficient and ecofriendly method for the construction of 2,3-difunctionalized benzofuran derivatives in moderate to good yields from readily available 2-alkynylphenols has been developed. This tandem annulation process, featuring one pot, three steps, good functional group tolerance, and high atom economy, makes this transformation efficient and practical. Moreover, this protocol is scalable, illustrating its potential applications in synthetic and pharmaceutical chemistry.