Water-Soluble Peptide-Coated Nanoparticles: Control of the Helix Structure and Enhanced Differential Binding to Immune Cells

Abstract

The stabilizing action of C(α)-tetrasubstituted α-amino acids inserted into a sequence of short peptides allowed for the first time the preparation of water-soluble nanoparticles of different materials coated with a helix-structured undecapeptide. This peptide coating strongly favors nanoparticle uptake by human immune system cells.