Radical-Induced Metal and Solvent-Free Cross-Coupling Using TBAI–TBHP: Oxidative Amidation of Aldehydes and Alcohols with <i>N</i>-Chloramines via C–H Activation

Abstract

A solvent-free cross-coupling method for oxidative amidation of aldehydes and alcohols via a metal-free radial pathway has been demonstrated. The proposed methodology uses the TBAI-TBHP combination which efficiently induces metal-free C-H activation of aldehydes under neat conditions at 50 °C or ball-milling conditions at room temperature.