Change of Selectivity in Modified Cyclodextrin Catalyst

Abstract

0-Cyclodextrin having a hydroxamate functional group was newly prepared and its catalytic activity for hydrolysis of a series of mono-or dinitrophenyl acetates was estimated.Relative enhancement of catalytic hydrqlysis, kcatlCD-hydroxamate)/kcatlCDl, was very sensitive to the substrate structure, e.g., lacation of substituent nitro groupls), being 230, for p-nitro; 130, 2.3-dinitro; 66, 3,4-dinitro; and 36 for 2.5-dinitro.The reaction mechanism was discussed.