Determination of Benzodiazepines by Derivative Spectroscopy*

Abstract

In this work, a rapid method is described for the quantitative determination of benzodiazepines, by means of derivative spectroscopy, and the application of this technique towards the study of the aforementioned substances in biological fluids. Diazepam, chlordiazepoxide, nitrazepam and clorazepate may be identified and quantitated at concentrations of 0.2 mg/L or greater.