Scrapie in Mice: Ultrastructural Observations in the Cerebral Cortex

Abstract

SummaryCerebral cortex obtained from scrapie infected mice was examined in the electron microscope. Three structures of unknown origin and significance were observed: (a) enlarged cell processes containing particles and rods, (b) enlarged cell processes occupied by varicose tubules filled with moderately dense material and (c) oval bodies formed by parallel bands and fibrils which were usually but not always, in a ring-like arrangement. These structures were generally associated in one way or another with synaptic terminals, but on rare occasions, they were found in unidentified cell processes. The possible significance of the presence of these structures in scrapie infected mouse brain is discussed.