Antihemostatic Effect of Heparin Counteracted by Adenosine Triphosphate.

Abstract

In the present paper the anti-hemostatic effect of heparin on rat tail preparations was studied. It was confirmed that the antihemostatic effect of heparin is not removed after several washes with saline solutions and it was shown that its activity is closely related to the sulfate groups of the heparin molecule. The coagulation time of samples collected from oozing blood in the heparin-treated tail remained in the normal range.