Paclitaxel for the Treatment of Progressive or Recurrent Childhood Brain Tumors: A Pediatric Oncology Phase II Study

Abstract

Paclitaxel is well tolerated in children with recurrent or progressive brain tumors at this dosage and schedule and may result in short-term disease stabilization in this patient population. The lack of a significant number of patients with measurable disease regression, however, precludes it from being identified as an active agent when administered as a single agent by 24-hour continuous infusion.