Clinical Use of Human Prothrombin Complexes

Abstract

IN previous communications1 , 2 we have reported preliminary observations on the use of a prothrombin complex, factors II-VII-IX-X, prepared as an eluate from barium sulfate by the method of Surgenor et al.3 This report concerns clinical studies with such prothrombin preparations, combined with additional results obtained with a new, improved concentrate of prothrombin complex factors ( II, VII, IX and X) obtained by Chromatographic isolation from fresh human plasma by the method of Melin.4 A deficiency of one or more components of the prothrombin complex may complicate many clinical states: cirrhosis; hepatitis; biliary obstruction; malabsorption; childbirth; and the preoperative and postoperative . . .