Anatomic Changes Produced in Mice Treated with Excessive Doses of Cortisone

Abstract

1. The administration to mice of Cortisone in doses approximately 50 times the dose for humans produced a striking lymphopenia, loss in body weight, atrophy of thymus and spleen, and diminution in size of adrenal cortex, salivary glands, pituitary, and hibernating fat bodies. A number of histologic changes are briefly described.