Transfer of Acquired Resistance to Transplantable Leukemia in Mice.

Abstract

It has been demonstrated that graduated doses (cell-immunization) of leukemic cells1 and certain normal tissues2, 3 can induce resistance to transplantable leukemia in normally susceptible mice. Following cell-immunization injected leukemic cells immediately develop small lesions which soon become necrotic.4 Lesions do not form immediately following leukemic inoculation of strain C58 mice made resistant by Sto-Li foetal tissues. Once resistance to line I leukemia has been established by means of graduated cell doses it is permanent, while resistance caused by normal tissue implantation may be only temporary with a peak of effectiveness in C58 mice 3 days after implantation of Sto-Li tissue (unpublished data). Of further interest in this problem is the question: Can resistance induced by these 2 methods be transferred to normally susceptible mice?Accordingly, spleen and liver were removed from cell-immunized mice, minced and injected into susceptible C58 mice. Another group of C58 mice was given injections...