In vivo Activity of Streptothricin Against Brucella abortus.

Abstract

Streptothricin, an antibiotic substance obtained from a soil Actinomyces, has been tested against Brucella abortus both in vitro and in vivo with favorable results. Experiments with incubating eggs established that the toxicity of streptothricin is low enough to make possible the administration of doses sufficient to destroy Br. abortus in the living tissues. Studies with guinea pigs indicated that streptothricin offers considerable promise as an antibiotic agent against brucellosis in animals.