Intramolecular Cyclization during α-Hydroxylation of 17β-Acetylsteroids with Diacetoxyphenyliodine - Concepedia

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Intramolecular Cyclization during α-Hydroxylation of 17β-Acetylsteroids with Diacetoxyphenyliodine

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References

1985

Year

A. M. Turuta, A. V. Kamernitzky, A. V. Zhulin

Diacetoxyphenyliodine/potassium Hydroxide/methanolEnantioselective SynthesisBioorganic Chemistry17β-Acetyl- 17α-HydroxysteroidsNatural SciencesOrganic ChemistryIntramolecular CyclizationChemical BiologyPharmacologySteroidal Spiro-oxetan-3′-onesSteroid Metabolism

Abstract

Steroidal spiro-oxetan-3′-ones are prepared in good yield by reaction of 17β-acetyl- 17α-hydroxysteroids with diacetoxyphenyliodine/potassium hydroxide/methanol at room temperature.