Effect of Chlorothiazide on the Edema of Cirrhosis, Nephrosis, Congestive Heart Failure and Chronic Renal Insufficiency

Abstract

CHLOROTHIAZIDE (6-chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide), a nonmercurial diuretic agent, has aroused considerable interest since preclinical studies1 demonstrated a potent chloruretic as well as natriuretic effect.Chlorothiazide is only a moderate carbonic anhydrase inhibitor in vitro, having about ten times the activity of sulfanilamide and one twenty-fifth the potency of acetazolamide.2 The drug appears to be distributed in extracellular fluid. It is concentrated in liver but not in erythrocytes. It is excreted substantially in urine and also in bile. It does not appear in cerebrospinal fluid, aqueous humor or fat. The drug does not possess analgesic, anticonvulsant or antihistaminic activity, nor does it act . . .