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Effect of Aliphatic Oxime and Isatin Thiosemicarbazones on Vaccinia Infection in the Mouse and in the Rabbit
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1953
Year
Veterinary VaccineAntiparasitic AgentImmunologyPharmacotherapyAntiviral DrugIsatin ThiosemicarbazoneIsatin ThiosemicarbazonesNeuroimmunologyParasitologyParasitic ProtozoaNeurovirologyMedicineVirologyNeuropharmacologyVaccinia InfectionPharmacologyVaccinia VirusVaccinationAliphatic OximeVeterinary ScienceAntiviral ResponseAntiviral TherapySerial Passage
Summary1. Serial passage of vaccinia virus intracerebrally in mice treated with isatin thiosemicarbazone results in a gradual diminution in the amount of virus demonstrable in the brain. 2. Treatment with isatin thiosemicarbazone fails to protect rabbits inoculated intracerebrally with vaccinia virus. 3. Aliphatic oxime thiosemicarbazones may be as effective as benzene or heterocyclic derivatives as chemoprophylactic agents against vaccinia virus in mice.