Isoenzymes and Myocardial Infarction

Abstract

PLASMA and serum enzyme-activity alterations have proved useful as laboratory parameters in the diagnosis of myocardial disease.1 Among the enzymes employed to reflect myocardial necrosis are aldolase, glutamic oxalacetic transaminase, lactic dehydrogenase and malic dehydrogenase. Although the quantitative and serial changes in blood enzymes observed in myocardial infarction are characteristic, they are not specific in that other states such as those of liver, biliary and pancreatic tract and skeletal muscle may result in similar changes. In addition, the administration of drugs such as chlorpromazine, promazine, bishydroxycoumarin, pyrazinamide and opiates may result in elevations of serum enzymes similar to those observed . . .