Novel Brønsted Acid Catalyzed Three-Component Alkylations of Indoles with<i>N</i>-Phenylselenophthalimide and Styrenes

Abstract

Novel and efficient Brønsted acid (p-TsOH) catalyzed inter- and intramolecular Friedel-Crafts alkylations have been developed to synthesize selenated three-component coupling and selenation-cyclization indole derivatives. Chemical removal of the phenylseleno moiety was investigated, and the reaction mechanisms were discussed.