Blocking Urinary Electrolyte Effects of Desoxycorticosterone with Progesterone in Rats.

Abstract

SummaryProgesterone partially blocked the effects of desoxycorticosterone acetate (DCA) on the urinary ratio of Na/K in adrenalectomized rats by simultaneously reversing Na retention and K loss. Progesterone alone at large doses caused DCA-like reductions of the Na/K ratio. Tests of various dosage combinations with DCA suggest that blocking efficiency of progesterone is limited by its DCA-like property. The compound appears to be a competitive inhibitor of DCA and a unique example of a steroid with blocking and DCA-like effects in rats.